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Project

Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis

Center:

NC-Carolina Institute for Developmental Disabilities, UCEDD/LEND

Fiscal Year:

2025

Contact Information:

Gabriel Dichter
[email protected]
919-966-5171

Project Description:

This grant seeks to investigate the effects of estradiol on perimenopausal-onset anhedonia and psychosis and reward-related brain functioning measured by simultaneous positron emission tomography and functional magnetic resonance imaging (PET-MR). Results of this project will increase our understanding of anhedonia and psychosis during the menopause transition and will have the potential to deliver validated molecular imaging targets to use in future mechanistic clinical trials of novel treatments for perimenopausal-onset anhedonia and psychosis.

Keyword(s):

Mental/Behavioral Health – General

Core Function(s):

Performing Research or Evaluation

Area of Emphasis

Health-Related Activities

Target Audience:

General Public

Unserved or Under-served Populations:

None

Primary Target Audience Geographic Descriptor:

Not Applicable