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Project

Evaluation of low protein diet with amnio acid supplementation on growth in individuals with urea cycle disorders

Center:

DC-Children's Research Institute, LEND

Fiscal Year:

2023

Contact Information:

Erin MacLeod
[email protected]
202-545-2500

Project Description:

This study aims to assess the relationships between diet composition (low-protein diet, with and without BCAA and/or EA supplementation) on growth in children with UCDs using data from the Urea Cycle Disorders Consortium (UCDC). Data analysis will utilize the UCDC database of children aged 1 to 5 with UCD and will compare the effect of a low protein diet with EAA and/or BCAA supplementation to a diet without supplementation on growth outcomes. Previous UCDC studies highlighted that progressive growth impairment in UCD patients is associated with disease severity and plasma BCAA levels, but did not find an association with diet. However, further research is needed to determine if the low protein diet composition affects growth of children with UCD.

Keyword(s):

Core Function(s):

Training Trainees, Performing Direct and/or Demonstration Services, Performing Research or Evaluation, Continuing Education/Community Training

Area of Emphasis

Education & Early Intervention, Health-Related Activities

Target Audience:

Students/Trainees (long or intermediate trainees), Community Trainees / Short term trainees, Professionals and Para-Professionals

Unserved or Under-served Populations:

None

Primary Target Audience Geographic Descriptor:

Single-County

Funding Source: