MECHANISMS OF INFLAMMATION IN SICKLE CELL DISEASE

2020

Sickle cell disease is characterized by chronic inflammation. High mobility group box 1 (HMGB1) is a nuclear protein that is important for maintaining DNA structure and function. However, during inflammation and injury HMGB1 is released from the cells. Once released it can act as a potent inflammatory agent that increases endothelial cell injury and death. We think SCD increases HMGB1 to increase endothelial cell injury and risk of RBC congestion and crisis. The goal of our study is to learn how HMGB1 increases inflammation, injures endothelial cells and increases vaso-occlusive crises in sickle cell disease.

Performing Research or Evaluation

Health-Related Activities

Professionals and Para-Professionals, Family Members/Caregivers, Adults with Disabilities, Children/Adolescents with Disabilities/SHCN

Racial or Ethnic Minorities, Disadvantaged Circumstances, Geographic Areas, Urban

Regional

Federal

N/A