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Project

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NEURODEGENERATION IN AGING DOWN SYNDROME (NIAD): A LONGITUDINAL STUDY OF COGNITION AND BIOMARKERS OF ALZHEIMER'S DISEASE

Center:
PA-LEND Center of Pittsburgh, LEND
Fiscal Year:
2019
Contact Information:
Benjamin Handen
[email protected]
412-235-5445
Project Description:
Adults with Down syndrome (DS) are at an extremely high risk for developing Alzheimer's disease (AD), with most individuals over age 40 evidencing neurofibrillary tangles and neuritic plaques (which are thought to be associated with the eventual appearance of AD symptoms). The goal of the current application is to recruit and follow 180 adults with DS and 40 biomarker controls to enable the identification of the longitudinal progression of AD in adults with DS using clinical, cognitive, imaging and genetic and biochemical biomarkers. This data is not only necessary to deepen our understanding of the pathophysiology of AD in DS, but may also offer information that will prove useful in the design of treatment trials to slow or prevent AD in DS.
Keyword(s):
Core Function(s):
Performing Research or Evaluation
Area of Emphasis
Health-Related Activities
Target Audience:
Family Members/Caregivers, Adults with Disabilities, Children/Adolescents with Disabilities/SHCN
Unserved or Under-served Populations:
Specific Groups
Primary Target Audience Geographic Descriptor:
Regional
Funding Source:
Federal
COVID-19 Related Data:
N/A
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