Biomechanical Analysis of Gait in Individuals with Duchenne Muscular Dystrophy
Project Description:
This is a muti-center longitudinal study to assess changes in walking, gross motor function, health-related quality of life and participation. DMD is an X linked recessive disease of muscle characterized by a progressive loss of functional muscle mass. Recently corticosteroids have been shown to reduce the expected loss of muscle strength, extend the time that ambulation is maintained and minimize or eliminate spinal deformity in individuals with DMD. The side effects of such treatment preclude use in some patients. To date, differences in gait patterns and other markers of disease progression between boys on corticosteroids and those not utilizing such treatment not been objectively quantified. This lack of knowledge is a major obstacle to determining the most effective treatment for subsets of boys with DMD. The purpose of this study is to characterize the progression of DMD in boys on and off corticosteroids, using objective outcome measures in order to ascertain the optimal type and timing of treatment to promote long-term ambulation, enhance function and improve quality of life.
Keyword(s):
Duchenne Muscular Dystrophy, Gait function, quality of life
Core Function(s):
Performing Research or Evaluation
Area of Emphasis
Quality Assurance, Health-Related Activities, Quality of Life
Target Audience:
Students/Trainees (long or intermediate trainees), Professionals and Para-Professionals, Children/Adolescents with Disabilities/SHCN
Unserved or Under-served Populations:
Racial or Ethnic Minorities, Specific Groups
Primary Target Audience Geographic Descriptor:
Regional
COVID-19 Related Data:
N/A
