Project Description:
FRAGILE X RESEARCH
The Fragile X Research and Treatment Center, under the leadership of Randi Hagerman, MD, is currently working on eight research projects. Research findings have been presented at 22 professional or community forums this year to date (attended by 2,480 professionals and para-professionals and 375 family members) and in 13 journal articles.
One of the projects is a collaborative grant from NIH with the Waisman Center (Abbedutto, overall PI, and Hagerman, PI at UC Davis), entitled ?Social-Affective Basis of Word Learning in Fragile X Syndrome and Autism.? This four-year project is taking place at both locations (Wisconsin and California) and began in the summer of 2008. The Fragile X Center also has a grant from NICHD for a newborn Fragile X screening project. This project, which began in November 2008, is in collaboration with the MRDDRC and the UCEDD at the University of Washington in Seattle and with Rush University in Chicago. Newborn screening is in progress at both Rush and at UC Davis Medical Center. A third grant is for a study of R-Baclofen as a targeted treatment in adolescents and adults with Fragile X Syndrome and is funded by Seaside Therapeutics.
The Fragile X Center is also carrying out a number of studies in premutation, including children, adults, and aging individuals. The premutation can cause neurodevelopmental disorders including autism and ADHD and it can also cause the Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) in aging carriers. Our research includes the molecular, neuroimaging and neurocognitive correlates of premutation involvement. We presented our research results on Fenobam treatment for Fragile X Syndrome at the National Fragile X Foundation?s international conference in St Louis in September 2008 to an international audience with 20 countries represented.
Internationally, we are carrying out high risk screening for individuals at risk for either premutation involvement or full mutation involvement. This screening is currently being conducted in Guatemala, Spain, Thailand, and India, and may be expanded into Chile in the near future.
Core Function(s):
Performing Research or Evaluation, Developing & Disseminating Information
Area of Emphasis
Health-Related Activities
Target Audience:
Students/Trainees (long or intermediate trainees), Community Trainees / Short term trainees, Professionals and Para-Professionals, Family Members/Caregivers, Adults with Disabilities, Children/Adolescents with Disabilities/SHCN, Legislators/Policy Makers, General Public
Unserved or Under-served Populations:
Racial or Ethnic Minorities, Disadvantaged Circumstances, Limited English, Geographic Areas, Rural/Remote
Primary Target Audience Geographic Descriptor:
Not Applicable
COVID-19 Related Data:
N/A
