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Product

Journal: T2-FLAIR hyperintensities in the inferior cerebellar peduncles and their association with clinical symptoms, molecular and MRI markers in male FMR1 premutation carriers

Center:

CA-UC Davis at the MIND Institute, UCEDD/LEND

Fiscal Year:

2026

Contact Information:

Amber Fitzgerald
[email protected]
916-703-0244

Product Description:

Only carriers with FXTAS revealed ICP hyperintensities at last visits. Furthermore, ICP hyperintensity was associated with brain atrophy, increased white matter disease, the MCP sign, FXTAS stage, abnormal gait, lower cognitive functioning and faster age-related increase in anxiety and depression scores. Finally, carriers with ICP hyperintensities had significantly higher CGG repeat length than carriers without ICP hyperintensities.

Keyword(s):

FMR1 premutation; FXTAS, MRI; ataxia; fragile X-associated tremor/ataxia syndrome, inferior cerebellar peduncle; white matter.

Product/Publication Type(s):

Peer-reviewed publications in scholarly journals Published/In Press

Target Audience:

Professionals

Alternative Format:

To Obtain Copies (URL or Email):

https://doi.org/10.3389/fnmol.2026.1720370

COVID-19 Related Data:

N/A

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Mailing address:
PO Box 8787
Silver Spring, MD 20907-8787