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Product

Journal: Novel Gain of Function Mouse Model of KCNT1-Related Epilepsy

Center:

CA-UC Davis at the MIND Institute, UCEDD/LEND

Fiscal Year:

2026

Contact Information:

Jill Silverman
[email protected]
916-734-8531

Product Description:

There are currently no therapeutics to prevent the progression of KCNT1-related epilepsy, therefore, the scientific community requires a novel mouse model that is well characterized, in vitro and in vivo, to screen and assess targeted therapeutics. Herein, we engineered a novel mouse to assess developmental and adult phenotypes resulting from the G288S/G269S variant, in vitro and in vivo, to advance translation toward therapeutic testing for individuals with KCNT1-related epilepsy.

Keyword(s):

Product/Publication Type(s):

Peer-reviewed publications in scholarly journals Published/In Press

Target Audience:

Consumers/Families

Alternative Format:

To Obtain Copies (URL or Email):

https://doi.org/10.1101/2025.07.22.666003

COVID-19 Related Data:

N/A

1100 Wayne Avenue, Suite 1000 Silver Spring, MD 20910

Mailing address:
PO Box 8787
Silver Spring, MD 20907-8787