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AUCD’s Maternal and Child Health Engagement supports the Autism CARES Programs, including LEND and DBP Programs.

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Project

Gene Expression Analysis in a Neuroinflammation Model of Autism

Center:

NE-Munroe-Meyer Institute of Genetics & Rehabilitation, UCEDD/LEND

Fiscal Year:

2013

Contact Information:

Anna Dunaevsky
[email protected]
402-559-1071

Project Description:

Autism spectrum disorder (ASD) is a neurosensory developmental disorder with both genetic and environmental etiologies. Increasing evidence points to immunological dysfunction in ASD that may result in inflammatory-like state. Mouse models for prenatal exposure to maternal infection or inflammation have shown that the challenged offspring demonstrate an altered behavioral phenotype characteristic of ASD. The objective of this pilot study is to identify the changes in gene expression in brains of offspring challenged by Maternal Immune Activation in mice.

Keyword(s):

Gene expression, autism

Core Function(s):

Performing Research or Evaluation

Area of Emphasis

Health-Related Activities

Target Audience:

Not Applicable

Unserved or Under-served Populations:

Specific Groups

Primary Target Audience Geographic Descriptor:

National