Tissue Engineering and Cellular Reprogramming (TECR) Core

Rose F. Kennedy Intellectual and Developmental Disabilities Research Center
Center URL: http://einstein.yu.edu/centers/iddrc
Core URL: http://einstein.yu.edu/centers/iddrc/research-cores/tissue-engineering-cellular-reprogramming.aspx

Core Personnel
Core Director: Mark Mehler
Core Associate Director: Solen Gokhan, M.D.
Core Associate Director: Aldrin Molero, M.D., Ph.D.

The Tissue Engineering and Cellular Reprogramming (TECR) Core provides innovative and state-of-the-art interdisciplinary expertise, equipment, essential molecular, cellular and systems-level reagents and associated equipment and dedicated space techniques for the study of cell and tissue preparations from both human and animal models of intellectual and developmental disorders. These services are designed to facilitate research projects employing a wide variety of experimental approaches ranging from the use of cellular and molecular biology techniques, genomic, epigenomic and systems biological analyses and neurophysiological approaches to the study of distinct animal and human cellular and tissue preparations. The core supplies these services in conjunction with other RFK-IDDRC core facilities and specialized support services by providing extensive training, oversight, facilities and novel and unique resources to expedite these interdisciplinary goals.

1. To provide state-of-the-art equipment and expertise to facilitate the study of a broad variety of cell and tissue types from individuals with intellectual and developmental disabilites as well as from cell and animal models
2. To facilitate combined use of in vitro and in vivo approaches to study individual genes and epigenetic modulators during brain development in health and genetic disease
3. To develop novel therapeutic strategies and promote neural cell protection and/or neural regeneration through genetic and epigenetic cellular reprogramming and tissue engineering

• In vitro dissociated cell culture, slice and organotypic and whole embryo cultures
• Embryonic stem (ES) cell experimental applications
• Viral vector cellular manipulations for in vitro and in vivo applications
• Human fetal cell experimentation
• Fluorescence-activated cell sorting (FACS) for analytical and preparatory experimental approaches
• Quantitative analysis of gene expression

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Last Edited: 09/05/12 12:00 AM by Corina Miclea