Brain Somatic Mosaicism and its Role in Psychiatric Disorders (Collaborative U01)

Submission Date: June 24, 2014

Multiple Deadlines:  June 24, 2014; February 24, 2015; October 23, 2015; June 24, 2016; February 24, 2017, by 5:00 PM local time of applicant organization.

Award Ceiling:TBD

This funding opportunity announcement (FOA) invites Cooperative Agreement (U01) applications from multi-disciplinary and synergistic teams of investigators proposing to identify and characterize the full spectrum of somatic variation in human brain samples and to assess the relationship of such variation with the pathophysiology of neuropsychiatric disorders. This FOA seeks to support applications exploring the extent of somatic variations across different brain regions in one or more psychiatric disorders using state-of-the-art genomic, computational and single-cell approaches. Awards made under this FOA will be governed by a Brain Somatic Mosaicism (BSM) Network Steering Committee to accelerate scientific progress through the coordination of research strategies, analytical methods and data. The ultimate goal of this FOA is to address gaps in our understanding of the role of somatic genomic perturbations in the etiology of neuropsychiatric disorders. This FOA should be used when two or more sites are needed to complete the study. Accordingly, the collaborating studies share a specific protocol across the sites and are organized as such in order to increase sample size, accelerate recruitment, or increase sample diversity and representation. Each site has its own Program Director/Principal Investigator and the program provides a mechanism for cross-site coordination, quality control, database management, statistical analysis, and reporting.

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