Research to Improve the Care of Persons at Clinical High Risk for Psychotic Disorders (Collaborative R01)

Submission Date: January 6, 2014

Award Ceiling: TBD

Given the highly disruptive and disabling nature of psychotic disorders, early intervention has been recommended as a means of preventing psychosis onset among at-risk individuals, as well as averting other adverse outcomes such as mood syndromes, substance abuse disorders, and functional decline in social, academic, and vocational domains. This funding opportunity announcement, along with the companion announcements, aims to support research that will inform a step-wise approach to early psychosis intervention in the United States. The goals of this initiative are to encourage applications that test the effectiveness of interventions that target symptomatic and functional difficulties associated with clinical risk states for psychosis; test hypotheses regarding mediators/mechanisms of action of these interventions; create an evidence base to inform stepped-care models of early psychosis intervention; and determine the feasibility for implementing such approaches in community-based treatment settings.

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