Bioenergetics, Fatigability, and Activity Limitations in Aging (R03, R01, R21)

Submission Date: September 1, 2012

R01 applications proposing to study bioenergetic factors underlying increased fatigability and activity limitations in aging. Increased fatigability is a significant cause of restricted physical and cognitive activity in older adults.

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R03 grant mechanism supports different types of projects including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology.

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R21 applications proposing to study bioenergetic factors underlying increased fatigability and activity limitations in aging. Increased fatigability is a significant cause of restricted physical and cognitive activity in older adults. Alterations in bioenergetics the production and utilization of energy, and the regulation of these processes may contribute significantly to increased fatigability.

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