Researchers Identify Gene Variant Associated with Autism and Gastrointestinal Dysfunction

March 13, 2009

A study led by researchers at the University of Southern California and Vanderbilt University have identified a specific gene variant that links increased genetic risk for autism with gastrointestinal conditions.

The findings suggest that disrupted signaling of the MET gene may contribute to a syndrome that includes autism and co-occurring gastrointestinal dysfunction, said principal investigator Pat Levitt, director of the Zilkha Neurogenetic Institute at the Keck School of Medicine of USC, and chair-designate of the Department of Cell and Neurobiology.

While gastrointestinal conditions are common among individuals with autism, researchers have long debated whether co-occurring gastrointestinal dysfunction represents a unique autism subgroup, according to Levitt and lead author Daniel Campbell.

"Gastrointestinal disorders don't cause autism. Autism is a disorder of brain development," Levitt said. "However, our study is the first to bring together genetic risk for autism and co-occurring GI disorders in a way that provides a biologically plausible explanation for why they are seen together so often."

In the brain, the MET gene is expressed in developing circuits that are involved in social behavior and communication. Disturbances in MET expression result in alterations in how these critical circuits develop and mature, Levitt explained. Research indicates that MET also plays an important role in development and repair of the gastrointestinal system.

Researchers analyzed medical history records from 214 families in the Autism Genetic Resource Exchange. They found that a variant in the MET gene was associated with autism specifically in those families where an individual had co-occurring autism and a gastrointestinal condition.

The study brings researchers closer to understanding the complex genetic risks for autism. However, further research is needed, as different combinations of genes are likely to result in different types of autism features, Levitt said.

"We believe that there are other genes that will help identify different subgroups of individuals who have autism spectrum disorder," he said. "We also believe that there needs to be research looking at whether the children with co-occurring GI dysfunction and autism have unique features that will help us predict what treatments will be best for them."

The study was funded by the Simons Foundation, the Nancy Lurie Marks Foundation, the Dan Marino Foundation's Marino Autism Research Institute, the National Institute of Mental Health and the National Institute of Child Health and Human Development.

The study is published in the March issue of the journal Pediatrics.