BIOGRAPHICAL SKETCH
Give the following information for the key personnel and consultants and collaborators. Begin with the principal investigator/program director. Photocopy this page for each person.

NAME POSITION TITLE
Dianne M. McBrien, MD Clinical Associate Professor of Pediatrics

EDUCATION (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
YEAR
INSTITUTION AND LOCATION DEGREE CONFERRED FIELD OF STUDY
University of Notre Dame, Notre Dame, IN BA 1987 ENGLISH
Mayo Medical School, Rochester, MN MD 1991 PEDIATRICS


RESEARCH AND/OR PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience, and honors. Key personnel include the principal investigator and any other individuals who participate in the scientific development or execution of the project. Key personnel typically will include all individuals with doctoral or other professional degrees, but in some projects will include individuals at the masters or baccalaureate level provided they contribute in a substantive way to the scientific development or execution of the project. Include present membership on any Federal Government public advisory committee. List, in chronological order, the titles, all authors, and complete references to all publications during the past three years and to representative earlier publications pertinent to this application. DO NOT EXCEED TWO PAGES.

Professional Experience:
2005-present Clinical Associate Professor of Pediatrics, Department of Pediatrics, University of Iowa, College of Medicine
1998-2005 Assistant Professor of Clinical Pediatrics, Department of Pediatrics, University of Iowa, College of Medicine
1997-1998 Pediatric Associate, Department of Pediatrics, University of Iowa, College of Medicine
1996-1997 Fellow Associate, Department of Pediatrics, University of Iowa, College of Medicine
1994-1996 Fellow, Division of Developmental Disabilities, Department of Pediatrics, University of Iowa, College of Medicine
1991-94 Resident, Pediatrics and Adolescent Medicine, Mayo Graduate School of Medicine

Bibliography:
Articles
Van Dyke DC, McBrien DM, Sherbondy A. Issues in sexuality in Down syndrome. Down Syndrome Research and Practice 3(2):65-69, 1995.
(also translations in journals in Italian and Polish)
Van Dyke DC, Sherbondy A, McBrien DM, Petersen MC. Questions about the medical treatment of adults with Down Syndrome (Cuestiones sobre el tratamiento medico de los adultos con sindrome de Down) Sindrome De Down, Revista. 13(2):37-43, 1996. (Spanish)
Van Dyke DC, Bonthius N, Bonthius D, McBrien D, Dyken ME. Alcohol and anticonvulsant medication use during pregnancy: effects on the growth and development of infants and children. Infants and Young Children 9(2):43-50, 1996.
Van Dyke DC, Siddiqi S, Liston J, Harper D, McBrien DM. Regional Down syndrome clinics. Down Syndrome Quarterly 2(3):1-2, 1997.
Van Dyke DC, McBrien DM, Siddiqi S, Petersen MC, Harper DC. Funciones sociales, emocionales y sexuales de individuous con Sindrome de Down durante la adolescencia y la adultez joven (Important Issues in the Adolescent and Young Adult with Down Syndrome). Revista de Sindrome de Down . (In Spanish), 151:56,1998.
Van Dyke DC, McBrien D, Doolittle D, Sherbondy A, Eberly S. Children with special health care needs and managed care. Clinical Pediatrics, 1998;38:161-163.
Fisher E, Van Dyke DC, Matzen J, Sears L, Lin-Dyken D, McBrien D. Recent research on the etiologies of autism, Infants and Young Children, 1999;11(3):1-8.
Siddiqi S, Van Dyke DC, Donohoue P, McBrien D. Premature sexual development in individuals with neurodevelopmental disabilities, Developmental Medicine and Child Neurology, 1999;41:392-395.
McBrien DM, Bonthius DJ. Seizures in Infants and Young Children. Infants and Young Children. 2000;13(2):21-31.
Bosch J, Mraz R, Masbruch J, Tabor A, Van Dyke D, McBrien D. Constipation in young children with developmental disabilities. Infant and Young Children 2002;15(2):66-77.
Wadsworth JS, McBrien DM, Harper DC. Vocational Guidance and Employment of Persons with a Diagnosis of Prader-Willi Syndrome. The Journal of Rehabilitation 2003;69(1):15-21.

Book Chapters
McBrien DM, Van Dyke DC, Mattheis P. Down Syndrome. In Disorders of Development and Learning: A Practical Guide to Assessment and Management, 2nd edition. Wolraich ML, (Ed.) Mosby, St. Louis, MO, p 316-345, 1996.
Van Dyke DC, McBrien DM, Mattheis P. Psychosexual Behaviors, Sexuality, and Management Issues in Individuals with Down Syndrome. Rondal JA, Perera J, Nadel L, Comblain A. Down Syndrome's: Psychological, Psychobiological, and Socio-educational Perspectives. Whurr Publishers Ltd. London 1996. (translation in Dutch) Psychoseksueel gedrag, seksuallliteit en het omgaan daarmee bij mensen met Down syndroom. Down Up, Bijlaghe NR. 8 , Somer 1997, pp.1-8.
Van Dyke DC, McBrien DM, Siddiqi S, Petersen MC. Sexuality in Individuals with Down Syndrome. In Down Syndrome: A Review of Current Knowledge. Rondal JA, Perera J, Nadel L. (eds). Whurr: London, 1998, pp. 33-47.
McBrien DM. Pediatric Physiology. In: Pinkham J [Editor]. Principles in Pediatric Dentistry. Philadelphia: Saunders, 1999, pp. 69-73.
McBrien, DM. Disorders in Mental Development: Down Syndrome. In: Disorders of Development and Learning, 3rd edition. Wolraich MD, (ed). B.C. Decker and Company, Hamilton Ontario, Canada. 2003, pp. 207-223
McBrien, DM. Developmental Delay--Suspected. In: Pediatric Clerkship Guide. Woodhead JC. (ed). Mosby, St. Louis, MO. 2003, pp. 210-223.
McBrien, DM. Developmental Disabilities. In: Pediatric Clerkship Guide. Woodhead JC. (ed). Mosby, St. Louis, MO. 2003, pp. 434-450.
McBrien, DM. Topics in Pediatric Physiology. In: Pediatric Dentistry: Infancy Through Adolescence. Pinkham J. (ed). Philadelphia, Saunders: 2005, pp. 89-95.

Abstracts
D McBrien, MD and D Zimmerman, MD. "The Effects of the Long-Acting GnRH Analogue Buserelin on Adult Height Expectation in Central Precocious Puberty." International Endocrine Society, San Antonio, Texas, 1992.
Van Dyke DC, Walloch CL, McBrien DM, Sato Y. Videofluoroscopic evaluation of swallowing and nasopharyngeal reflux in individuals with Down Syndrome. Down Syndrome Quarterly, 3:1:17, 1998.

Other
Van Dyke DC, McBrien DM. Down syndrome update. American Academy for Cerebral Palsy and Developmental Medicine News. 46:1:8-9. 1996.
McBrien DM. The Down Syndrome Clinic at the University of Iowa. Down Syndrome News, April 1996.
Van Dyke DC, McBrien DM, Eberly SS. State of Iowa Children's Health Insurance Program (SCHIP), Healthy and Well Kids in Iowa (Hawk-I). EPSDT Newsletter, 1998.
McBrien DM. Medical Issues in International Adoption. EPDST Care for Kids Newsletter, 1999;6:1.
McBrien DM. Attention Problems in Down Syndrome: Is this ADHD? Group News. 2001;4(2):5-7.
McBrien, DM. Early Intervention and the Needs/Abilities of Those with Mental Retardation. Radio interview on KXIX radio, UI Health Care Today, 3/3/04.
McBrien, DM. Resource Can Aid Physicians in Discussing Down Syndrome. Americian Academy News. October 2005
McBrien, DM. National Down Syndrome Month. Radio interview on KXIX radio, UI Health Care Today, 10/18/05
McBrien, DM, Mental Retardation. Radio interview on KXIX radio, UI Health Care Today, 4/3/06