Chinfei Chen MD, PhD

Assistant Professor of Neurology

Children's Hospital Intellectual and Developmental Disabilities Research Center
Harvard Medical School
Children's Hospital Boston
Enders 2
300 Longwood Ave.
Boston, MA 02115
617-355-8137 (tel)

Biography/Curriculum Vitae:

Research Interests:
Systems Neurobiology, Circuit Development

Narrative of Current Research Efforts:

The precise relay of information from one area of the brain to another is important for normal neurological function.  Disruption of this communication can lead to cognitive disorders such as mental retardation and behavioral abnormalities.  We use the murine visual system to identify and characterize mechanisms important in the relay of visual information from the retina to the visual cortex via the retinogeniculate synapse in the lateral geniculate nucleus.  One objective of our research is to understand how neuromodulatory inputs from ascending projections in the brainstem can alter the nature of visual information transmitted to the visual cortex.

Major Honors and Awards:

Representative Publications:

Chen, C. and Regehr, W., 2000. Developmental remodeling of the retinogeniculate synapse. Neuron. 28, 955-966.

Carter, A. R., Chen, C., Schwartz, P. M. and Segal, R. A., 2001. Brain- derived neurotrophic factor modulates cerebellar plasticity and synaptic ultrastructure. J Neurosci. 22, 1316-1327.

Chen, C., Blitz, D. M. and Regehr, W., 2002. Contributions of receptor desensitization and saturation to plasticity at the retinogeniculate synapse. Neuron. 28, 779-788.

Chen, C. and Regehr, W., 2003. Presynaptic modulation of the retinogeniculate synapse. J Neurosci. 23, 3130-3135.

Lu, C., Huang, X., Ma, H., Gooley, J., Aparcio, J., ROof, D., Chen, C., Chen, D. and Li, T., 2003. Normal retinal development and retinofugal projections in mice lacking the retina- specific variant of actin- binding LIM domain protein. Neuroscience. 120, 121-131.

Hooks, B. and Chen, C., Distinct roles of activity in developmental synaptic remodeling.

Created 3/20/2006 by
Last modified 12/27/2016 by Theresa Trapilo