Xinkun Wang Ph.D.

Genomics Coordinator

Xinkun Wang Kansas Intellectual and Developmental Disabilities Research Center
University of Kansas - Lawrence
Life Span Institute
1000 Sunnyside Ave
Lawrence, KS 66045
785-864-4589 (tel)
785-864-3578 (fax)

Biography/Curriculum Vitae:

Research Interests:
Based on the functional genomics technology available at the Genomics Core Facility and interdisciplinary collaborations with scientists in the Computer Science, Statistics and Bioinformatics fields, my main research interests on functional genomics and systems biology include: 1) Biological knowledge extraction from high-through genomics data; 2) Gene network construction and visualization; 3) Integrated analysis of heterogeneous high-throughput biological data.

Narrative of Current Research Efforts:
One of the main neurobiological problems I have been focusing on is a phenomenon termed selective neuronal vulnerability (SNV). In many neurological disorders and during the aging process, only certain neuronal populations are vulnerable and die. For example, in epilepsy, the CA1 region of the hippocampus suffers severe sclerosis as a result of recurrent seizures, while the adjacent CA3 region is relatively spared. Although common, little is known on its cause(s). Our functional genomics analyses have suggested that oxidative stress, signal transduction, and inflammatory response, are related to this phenomenon.

Major Honors and Awards:

Representative Publications:
Chen, X.-W., G. Anantha, and X. Wang. (2006) An effective structure learning method for constructing gene networks. Bioinformatics, 22(11):1367-74.

Wang, X., R. Pal, X.-W. Chen, N. Limpeachob, K. N. Kumar, and E. K. Michaelis. (2005) High intrinsic oxidative stress may underlie selective vulnerability of the hippocampal CA1 subregion. Molecular Brain Research, 140(1-2): 120-6.

Created 2/22/2006 by Douglas Brownyard
Last modified 3/14/2007 by Xinkun Wang