Tarik Haydar PhD

Assistant Professor of Pediatrics and Pharmacology

Tarik Haydar Children's National Medical Center
George Washington University School of Medicine and Health Sciences; Georgetown University Medical Center
111 Michigan Ave., NW
Washington, DC 20010
202-884-2383 (tel)
202-884-4988 (fax)

Biography/Curriculum Vitae:

Research Interests:
During embryonic development, a pool of rapidly dividing stem cells generates the complex architecture and function of the mammalian cerebral cortex. Understanding the molecular signals that control this process is a fundamental goal of developmental neurobiology. Our work is aimed at understanding how growth of the cerebral cortex is controlled in both wild-type mice and mutant mouse models of disease. We are particularly interested in the multiple progenitor cell types in the neocortical ventricular zone (VZ) and the factors that control their division and lineage progression during the course of development. We pursue these issues using a variety of cellular, molecular, and imaging techniques. In particular, we have a special focus on real-time analysis of molecules using in utero gene transfection and multiphoton imaging. The laboratory runs and maintains an LSM510 META NLO microscope from Carl Zeiss, Inc.

Narrative of Current Research Efforts:

Major Honors and Awards:
Graduate Fellowship, Medical College of Pennsylvania, 1992-1993
Graduate Fellowship, University of Maryland School of Medicine, 1993-1994
Graduate Fellowship, Membrane Biology Program, University of Maryland School of Medicine, 1994-1996
Graduate Fellowship, Neuroscience Program, University of Maryland School of Medicine, 1996-1997
Graduate Merit Award, University of Maryland School of Medicine, 1997

Representative Publications:
Selected peer-reviewed publications 

1. Cascone, P.J., Haydar, T.F., and Simon, A.E. (1993) Sequences and structures required for recombination between virus-associated RNAs. Science 260:801-805.

2. Haydar, T.F., Blue, M.E., Molliver, M.E. , Krueger, B.K., and Yarowsky, P.J. (1996) Consequences of trisomy 16 for mouse brain development: Corticogenesis in a model of Down syndrome.  Journal of Neuroscience 16:6175-6182.

3. Kuida, K., Haydar, T.F., Kuan, C.-Y., Gu, Y., Taya, C., Karasuyama, H., , Su., M. S.-S., Rakic, P., and Flavell R.A. (1998) Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase-9. These authors contributed equally. Cell 94:325-337.

4. Haydar, T.F., Bambrick, L.B., Krueger, B.K., and Rakic, P. (1999) Organotypic slice cultures for analysis of proliferation, cell death, and migration in the embryonic neocortex. Brain Research Protocols 4:425-437. (Published On-Line at Brain Research Interactive July 8, 1999).

5. Haydar, T.F., Kuan, C-Y., Flavell, R.A, and Rakic, P. (1999) The role of cell death in regulating the size and shape of the mammalian forebrain. Cerebral Cortex 9: 621-626.

6. Roth, K., Kuan, C.-Y., Haydar, T.F., D’Sa-Eipper, C., Shindler, K. S., Zheng, T.S., Kuida, K., Flavell, R.A., and Rakic, P. (2000) Epistatic and independent functions of Caspase-3 and Bcl-XL in developmental programmed cell death. PNAS 97: 466-471.

7. Haydar, T.F., Nowakowski, R.S., Yarowsky, P.J., and Krueger, B.K. (2000) Role of founder cell deficit and delayed neuronogenesis in microencephaly of the trisomy 16 mouse. Journal of Neuroscience 20(11): 4156-4164.

8. Haydar, T.F., Wang, F., Schwartz, M.L., and Rakic, P. (2000) Differential modulation of proliferation in the neocortical ventricular and subventricular zones. Journal of Neuroscience: 20(15): 5764-5774.

9. Whitmarsh, A.J., Kuan, C.-Y., Kennedy, N, Kelkar N., Haydar, T.F., Mordes, J.P., Appel, M., Rossini, A., Jones, S.N., Flavell, R.A., Rakic, P., and Davis, R.J. (2001) Requirement of the JIP1 scaffold protein for stress-induced JNK activation. Gene s and Dev. 15(18): 2421-2432.

10. Ang, E., Haydar, T.F., and Rakic, P. (2003) Four dimensional migratory coordinates of GABAergic interneurons in the developing mouse cortex. Journal of Neuroscience 23(13):5805-5815. These authors contributed equally.

11. Haydar, T.F., Ang, E., and Rakic, P. (2003) Mitotic Spindle Rotation and Mode of Cell Division in the Developing Telencephalon, PNAS 100: 2890-2895.

12. Gallo, V., and Haydar, T. (2003) GABA: Exciting in its own right. Journal of Physiology 550.3:665.

13. Cheng, A., Haydar, T.F., Yarowsky, P.J., and Krueger, B.K. (2004) Concurrent generation of subplate and cortical plate neurons in developing Trisomy 16 mouse cortex. Dev. Neurosci. 26(2-4): 255-265.

14. Haydar, T.F. (2005) Advanced microscopic imaging methods to investigate cortical development and the etiology of mental retardation, Ment. Retard. Dev. Disab. Reviews, 11: 303-316.

15. Liu, X., Wang, Q., Haydar, T.F., and Bordey, A. (2005) Nonsynaptic GABAergic signaling in the postnatal subventricular zone controls astrocyte-like cell proliferation, Nature Neuroscience 8(9): 1179-1187.

16. Gal, J.S., Morozov, Y.M., Ayoub, A.E., Chatterjee, M., Rakic, P., and Haydar, T.F. (2005) Molecular and morphological heterogeneity of neural precursors in the mouse neocortical proliferative zones. Journal of Neuroscience, 26(3): 1045-1056.

17. Harashima, C., Jacobowitz, J.M., Stoffel, M., Haydar, T.F., Chakrabarti, L., Siarey, R., Galdzicki, Z. (2006) Elevated expression of the G-Protein activated inwardly rectifying potassium channel 2 (GIRK2) in Cerebellar Unipolar Brush Cells of Down Syndrome Mouse Model. Cell. Mol. Neurobiol. in press

Created 1/5/2006 by Evette Mezger
Last modified 4/28/2006 by Tarik Haydar