Andrew L Alexander Ph.D.

Assistant Professor

Andrew L Alexander

Waisman Center
University of Wisconsin-Madison
1500 Highland Ave.
Madison, WI 53705
608-265-8233 (tel)
608-262-9440 (fax)
[email protected]
http://www.waisman.wisc.edu/

Biography/Curriculum Vitae:

Research Interests:

Narrative of Current Research Efforts:

My research is focused on the use of Magnetic Resonance Imaging (MRI) for mapping and measuring the functional and structural organization of the human brain. These techniques are being used to investigate the brain in both typically developing individuals and subjects with developmental disorders including autism. Functional MRI (fMRI) is used to assess brain regions associated with cognition and affect and their dysfunctions in these populations. Diffusion tensor MRI (DT-MRI) is being used to study the patterns of structural connectivity between brain activity regions. Anatomic imaging methods are used to assess longitudinal structural changes in brain regions. These measurements are ultimately compared with measures of affect, behavior and cognition in specific population groups.

Major Honors and Awards:

Representative Publications:

Thottakara, P., Lazar, M., Johnson, S.C. & Alexander, A.L. (2006). Probabilistic connectivity and segmentation of white matter using tractography and cortical templates. Neuroimage 29(3):868-878.

Lainhart, J.E., Lazar, M., Bigler, E.D. & Alexander, A.L. (2005). The Brain During Life in Autism: Advances in Neuroimaging Research. Book Chapter. In Recent Developments in Autism Research. Casanova MF, editor. Nova Science Publishers.

Lazar, M., Lee, J.H., & Alexander, A.L. (2005). Consistent cylindrical asymmetries in the diffusion tensor of the human brain. Magn Reson Med 54(4): 860-7.

Lazar, M. & Alexander, A.L. (2005). Bootstrap white matter tractography (BOOT-TRAC). Neuroimage 24:524-32.

Wu, Y.C., Field, A.F., Badie, B. & Alexander, A.L. (2004). Qualitative analysis of diffusion tensor orientation: theoretical framework. Magn. Reson. Med. 52(5):1146-55.

Lazar, M. & Alexander, A.L. (2003). An error analysis of white matter tractography methods: Synthetic diffusion tensor field simulations. Neuroimage 20(2): 1140-53.

Lazar, M., Weinstein, D.M., Tsuruda, J.S., Hasan, K.M., Arfanakis, K., Alexander, A.L. et al. (2003). White matter tractography using tensor deflection. Human Brain Mapping 18:306-21.

Witwer, B.P., Moftakhar, R., Hasan, K.M., Deshmukh, P., Arfanakis, K., Alexander, A.L. et al. Badie B. (2002). Diffusion tensor imaging of white matter tracts in patients with cerebral neoplasms. J. Neursurgery 97:568-75.

Alexander, A.L., Hasan, K., Lazar, M., Tsuruda, J.S. & Parker, D.L. (2001). Analysis of partial volume effects in diffusion-tensor MRI. Magn. Reson. Med. 45:770-80.

Alexander, A.L., Hasan, K., Kindlmann, G., Parker, D.L. & Tsuruda, J.S. (2000). A geometric comparison of diffusion anisotropy measures. Magn. Reson. Med. 44:283-91.