James T McCracken

Professor, Director, Child Psychiatry Division, Neuropsychiatric Institute

James T McCracken UCLA Intellectual and Developmental Disabilities Research Center
University of California, Los Angeles
Mail Code 175919
NPI, Rm 48-270
Los Angeles, CA 90024
310-825-0470 (tel)

Biography/Curriculum Vitae:

Research Interests:
Biological aspects of major psychiatric illnesses in children and adolescents

Narrative of Current Research Efforts:
McCracken's research focuses on the investigation of the neurobiological aspects of major psychiatric and developmental disorders, and their treatment, in children and adolescents. One approach is the application of pharmacogenetic analyses to understand treatment variability. McCracken's research also includes the study of normal and atypical brain development as a means to clarify the underlying etiology of disorders such as Attention Deficit Hyperactivity Disorder (ADHD) and Autism.

Recently, McCracken's laboratory has reported on the effects of gene variants in the 5HT2A gene predicting differences in efficacy and variants in the 5HT2C gene predicting weight gain associated with exposure to risperidone, an atypical antipsychotic, in children with autism.

Major Honors and Awards:

Representative Publications:

Loo SK, Fisher SE, Francks C, Ogdie MN, MacPhie IL, Yang M, McCracken JT, McGough JJ, Nelson SF, Monaco AP and Smalley SL (2004) Genome-wide scan of reading ability in affected sibling pairs with attention-deficit/hyperactivity disorder: unique and shared genetic effects. Mol Psychiatry, 9:485-93.

Greenhill LL, Vitiello B, Abikoff H, Levine J, March JS, Riddle MA, Capasso L, Cooper TB, Davies M, Fisher P, Findling RL, Fried J, Labellarte MJ, McCracken JT, McMahon D, Robinson J, Skrobala A, Scahill L, Varipatis E, Walkup JT and Zito JM (2003) Developing methodologies for monitoring long-term safety of psychotropic medications in children: report on the NIMH conference, September 25, 2000. J Am Acad Child Adolesc Psychiatry, 42:651-5.

Bergman RL, Piacentini J and McCracken JT (2002) Prevalence and description of selective mutism in a school-based sample. J Am Acad Child Adolesc Psychiatry, 41:938-46.

Levitt JG, Blanton RE, Caplan R, Asarnow R, Guthrie D, Toga AW, Capetillo-Cunliffe L and McCracken JT (2001) Medial temporal lobe in childhood-onset schizophrenia. Psychiatry Res, 108:17-27.

Created 7/27/2006 by Evette Mezger
Last modified 8/28/2006 by Dorwin Birt