Harley Kornblum

Associate Professor

Harley Kornblum UCLA Intellectual and Developmental Disabilities Research Center
University of California, Los Angeles
Mail Code 177019
Crump Institute, Rm 1126
Los Angeles, CA 90024
310-794-7866 (tel)

Biography/Curriculum Vitae:

Research Interests:
Williams Syndrome, Down Syndrome, Human Genome and Evolution

Narrative of Current Research Efforts:
The primary interests of the Kornblum laboratory are:
  1. Molecular Genetics of Neural stem cells
  2. Cell biology of Neural stem cells-survival, proliferation and differentiation
  3. Identity and plasticity of neural stem cells
  4. Repair of injury using Neural Stem Cell Transplantation
  5. Relationship between neural stem cells and brain tumors
  6. Identification of small molecules that influence neural stem cell differentiation

Major Honors and Awards:

Representative Publications:

Easterday MC, Dougherty JD, Jackson RL, Ou J, Nakano I, Paucar AA, Roobini B, Dianati M, Irvin DK, Weissman IL, Terskikh AV, Geschwind DH and Kornblum HI (2003) Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. Dev Biol, 264:309-22.

Hemmati HD, Nakano I, Lazareff JA, Masterman-Smith M, Geschwind DH, Bronner-Fraser M and Kornblum HI (2003) Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci U S A, 100:15178-83.

Karsten SL, Kudo LC, Jackson R, Sabatti C, Kornblum HI and Geschwind DH (2003) Global analysis of gene expression in neural progenitors reveals specific cell-cycle, signaling, and metabolic networks. Dev Biol, 261:165-82.

Imura T, Kornblum HI and Sofroniew MV (2003) The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP. J Neurosci, 23:2824-32.

Groszer M, Erickson R, Scripture-Adams DD, Lesche R, Trumpp A, Zack JA, Kornblum HI, Liu X and Wu H (2001) Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science, 294:2186-9.


Created 7/27/2006 by Evette Mezger
Last modified 8/28/2006 by Dorwin Birt