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Neurosensory disorders, particularly those creating deficits in hearing, vision, and balance/proprioception have devastating effects upon the individual's ability to interact with the environment and produce significant difficulties in communication and mobility, which in turn impact occupational and social functioning. Important advances have been made in the identification of genes producing neurosensory disorders, but the underlying pathogenesis is poorly understood. Basic research into the development of neurosensory systems, their function, and their maintenance, is needed in order to understand the molecular mechanisms underlying these disorders and to determine the optimal means of intervention. This project involves established researchers and junior investigators from the University of Nebraska Medical Center, Creighton University, and Boys Town National Research Hospital, who are combining and focusing their research efforts towards a common theme, the Molecular Biology of Neurosensory Systems. Core facilities allow each project to utilize various methodological approaches, including measures of gene transcription, localization of gene expression, and creation of appropriate animal models. A program of mentoring and professional interaction will enable junior investigators to achieve successful and independent careers. The result will be a continuing, self-sustaining, and competitive research Center that will stimulate excellence in all three participating institutions and throughout the State.
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