David H. Hall Ph.D.

Professor of Neuroscience

David H. Hall

Rose F. Kennedy Intellectual and Developmental Disabilities Research Center
Albert Einstein College of Medicine
1401 Pelham Parkway South
Kennedy 211
Bronx, NY 10461
718-430-2195 (tel)
718-430-8821 (fax)
[email protected]
http://neuroscience.aecom.yu.edu/faculty/primary_faculty_pages/hall.html

Biography/Curriculum Vitae:

Research Interests:
Correlative fine structure and serial section reconstruction at the electron-microscopic level; morphology of nervous system mutants of Caenorhabditis elegans.

Narrative of Current Research Efforts:
The soil nematode Caenorhabdidis elegans is a model system used to study the genetic control of cellular development. Our laboratory specializes in ultrastructural studies of the nervous system. We use serial thin sections, electron microscopy, and immunocytochemistry as primary tools to follow the development of identified neurons, particularly their axon outgrowth and synaptic connectivity.

We host the Center for C. elegans Anatomy, supported by NIH RR, and train students in anatomical methods for this system. Members of the lab are authoring the website www.WormAtlas.org. It displays nematode anatomy in great detail through multiple applications including Slideable Worm, a Handbook of all cells and tissues, a Glossary, and selected html texts of classic papers.

Wired Worm is a project aiming to complete the wiring diagram for the male adult nematode, working with Scott Emmons (Mol. Genetics, AECOM). SuperWorm will produce a 3D online browser for nematode anatomy, working with the Pittsburgh Supercomputing Center.

Major Honors and Awards:

Representative Publications:

Berry, K., Bulow, H.E., Hall, D.H. and Hobert, O. (2003) Intracellular tube formation requires a C. elegans CLIC ion channel homolog. Science 302: 2134-37.

Melendez, A., Talloczy, Z., Seaman, M., Eskelinen, E-L., Hall, D.H., and Levine, B. (2003) Autophagy genes are essential for dauer development and lifespan extension in C. elegans. Science 301: 1387-91.

Huang, C-c., Hall, D.H., Hedgecock, E.M., Kao, G., Karantza, V., Vogel, B., Hutter, H., Chisholm, A.D.,Yurchenco, P.D., and Wadsworth, W.G. (2003) Laminin ( subunits and their role in C. elegans development. Development 130: 3343-3358.

Starich, T., Miller, A., Nguyen, R.L., Hall, D.H. and Shaw, J.E. (2003) The C. elegans innexin gene product INX-3 is localized to gap junctions and is essential for embryonic development. Dev. Biol. 256: 403-417.

Herndon, L.A., Schmeissner, P.J., Dudaroneck, J.M., Brown, P.A., Listner, K.M., Paupard, M.C., Hall, D.H., and Driscoll, M. (2002) Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419: 788-794.

Aurelio, O., Hall, D.H., and Hobert, O. (2002) Immunoglobulin-domain proteins required for maintenance of ventral nerve cord organization. Science 295: 686-690.

Rolls, M.M., Hall, D.H., Victor, M., Stelzer, E.H.K., and Rappaport, T.A. (2002) Targeting of rough endoplasmic reticulum membrane proteins and ribosomes in invertebrate neurons. Mol. Biol. of the Cell 13: 1778-1791.

Nass, R., Hall, D.H., Miller, D.M. and Blakeley, R.D. (2002) Neurotoxin-induced degeneration of dopamine neurons in C. elegans. PNAS 99: 3264-3269.