Genome Analysis: Fluorescence In Situ Hybridization (FISH)
Baylor College of Medicine Intellectual and Developmental Disabilities CenterGenome Analysis: Fluorescence In Situ Hybridization (FISH)
Center URL: https://www.bcm.edu/research/centers/iddrc/
Core URL: http://mrrc.bcm.tmc.edu/cores/FISH.html
Core Personnel
Core Director: James Lupski, M.D., Ph.D.
Core Keywords
Genome Analysis; Fluorescence In Situ Hybridization; FISH
Core Description
The objective of the Fluorescence In Situ Hybridization (FISH) core is to provide high quality and cost effective state-of-the-art molecular cytogenetic analyses (as well as conventional chromosome analyses) to all MRDDRC investigators, to enhance research efforts on disorders related to mental retardation and developmental disabilities.
Services
The FISH core provides a “special skill support” enabling MRDDRC investigators to access important methodology for genome analyses. Major services offered by the FISH core are: - Provide analyses for detection and confirmation of submicroscopic DNA rearrangements; including deletions, duplications, and inversions;
- Provide genomic mapping by FISH in human and primate cell lines;
- Provide a simultaneous analysis of all of the chromosome end structures, or telomeres, by telomere FISH.
This core will continue to provide conventional cytogenetic analysis as well as fluorescence in situ hybridization including metaphase FISH analysis, interphase FISH analysis, FISH mapping, and telomere FISH.
Last Edited: 03/14/07 12:00 AM by Celine Coutte