Intellectual and Developmental Disabilities (IDD) Models Core

Center URL: http://www.waisman.wisc.edu/
Core URL: http://www.waisman.wisc.edu/cores-idd-models.htm

Core Personnel
Core Director: John Svaren, Ph.D.
Core Co-Director: Anita Bhattacharyya, Ph.D.
Core Co-Director: Qiang Chang, Ph.D.
Core Co-Director: Su-Chun Zhang, M.D., Ph.D.
Core Co-Director: Xinyu Zhao, Ph.D.

Core Description

The Intellectual and Developmental Disabilities (IDD) Models Core in the Waisman Center provides a number of resources to investigators within our center as well as to other campus investigators. First, the core provides mouse models of human conditions, along with behavioral testing capabilities to characterize these models and test new therapies. Second, we provide state-of-the-art stem cell technologies to support creation of induced pluripotent stem cell lines for IDD conditions as well as specialized genome editing services. Finally, we provide high quality, cost effective, microscopy technology and expertise for characterization of both stem cell and mouse models of IDD conditions.

Services

Cellular Imaging and Analysis Lab

Fluorescence/Brightfield and Confocal Microscopy
Fluorescence Quantitation
Cellular Imaging and Analysis Instrumentation
Consultation, Support and Training

Induced Pluripotent Stem Cells (iPSC) Services

iPSC cloning, including mycoplasma testing, marker immunofluorescence, and WiCell characterization (for University of Wisconsin researchers)
Gene mutation correction/induction
Endogenous site reporter insertion
Safe harbor site reporter insertion
Lineage-tracing dual insertion
Custom gene editing projects

Rodent Models